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个人信息

博士生导师
研究员
2018年获得“国家杰出青年基金”
Email: htliu@sibs.ac.cn
个人网页: http://lht.sippe.ac.cn

研究方向

光信号转导

刘宏涛

个人简介

2002年9月-2005年7月,河北师范大学,研究生/博士
2005年9月-2010年9月,美国加州大学洛杉矶分校,博士后
2010年10月-2011年7月,美国加州大学洛杉矶分校,staff research associate Ⅲ
2011年7月-今 中国科学院上海生命科学院植物生理生态研究所,研究员/课题组长
2012年入选中科院“百人计划”A类,并获上海市“浦江人才计划”支持,2013年获得国家基金委“优秀青年基金”支持。相关研究成果以通讯作者或第一作者发表在Science,Developmental Cell, Nature Plants, PNAS,Plant Cell,PLoS Genetics,Current Biology,Trends in Plant Science等国际期刊上。担任The Plant Cell 杂志客座编辑(Guest Editor)。

研究工作

不断变换的光照条件并对之做出相应反应是生物的基本特征。光对于植物尤为重要,不仅仅因为光是植物光合作用的能量来源,同时也因为光是非常重要的环境信号,调节植物的生长发育。所以植物如何对光做出反应以及光信号的传递机制是生物研究中最重要最基本的问题之一。实验室以拟南芥和玉米为对象,围绕光信号调控植物发育的分子机制,光信号传递的机制,及光信号转导与其他内外源信号的交叉整合展开植物分子发育研究。

主要成果

1. 解析紫外光UV-B信号传递机制。发现UV-B受体UVR8被UV-B激活后运动到细胞核中,在细胞核中直接结合转录因子BIM1/BES1和WRKY36,进而抑制它们的DNA结合能力。UVR8一方面抑制BIM1/BES1对细胞伸长基因(PRE5等)表达的激活而降低促进细胞伸长基因的表达,另一方面则通过解除WRKY36对伸长抑制基因HY5表达的抑制而促进HY5表达,最终实现对细胞伸长的抑制 (Developmental Cell, 2018; Nature Plants, 2018)。

2. 在蓝光与温度协同调控植物发育的机制研究方面取得进展。发现蓝光受体CRY1在温度响应中至关重要,CRY1-PIF4介导蓝光和温度协同调控植物生长(PNAS,2016);阐明了蓝光和温度通过调控生物节律维持植物生长发育与抗冻性之间动态平衡的新机制(Plant Cell, 2016)。

3.系统解析蓝光信号调控光周期诱导开花的CRY2-CIBs途径。发现bHLH类转录因子(CIBs)形成异源二聚体共同参与CRY2介导的光周期诱导开花(PLoS Genetics, 2013);发现两个独立进化的蓝光受体CRY2和ZTL共同调控CIB1而实现功能整合(PNAS,2013)。

    1.Liang T, Mei S, Shi C, Yang Y, Peng Y, Ma L, Wang F, Li X, Huang X, Yin Y, Liu H*. (2018) UVR8 interacts with BES1 and BIM1 to regulate transcription and photomorphogenesis in Arabidopsis. Developmental Cell. 44:1-12

    2.Yang Y, Liang T, Zhang L, Shao K, Gu X, Shang R, Shi N, Li X, Zhang P, Liu H*. (2018) UVR8 interacts with WRKY36 to regulate HY5 transcription and hypocotyl elongation in Arabidopsis. Nature Plants. 4:98-107

    3.Li X, Cai W, Liu Y, Li H, Fu L, Liu Z, Xu L, Liu H, Xu T, Xiong Y* (2017) Differential TOR activation and cell proliferation in Arabidopsis root and shoot apexes. Proc Natl Acad Sci U S A. 114(10):2765-2770

    4.Reqing He#, Xinmei Li#, Ming Zhong#, Jindong Yan, Ronghuang Ji, Xu Li, Qin Wang, Dan Wu, Mengsi Sun, Dongying Tang, Jianzhong Lin, Hongyu Li, Bin Liu, Hongtao Liu, Xuanming Liu*, Xiaoying Zhao*, Chentao Lin, A photo-responsive F-box protein FOF2 regulates floral initiation by promoting FLC expression in Arabidopsis. The Plant Journal, 2017, 91, 788-801

    5.Li X#, Ma D#, Lu S#, Hu X, Huang R, Liang T, Xu T, Tobin E, Liu H*. (2016) Blue Light- and Low Temperature-Regulated COR27 and COR28 Play Roles in the Arabidopsis Circadian Clock. The Plant Cell. 28(11):2755-2769.

    6.Ma D#, Li X#, Guo Y, Chu J, Fang S, Yan C, Noel J, Liu H*. (2016) Cryptochrome 1 interacts with PIF4 to regulate high temperature-mediated hypocotyl elongation in response to blue light. Proc Natl Acad Sci U S A. 113(1):224-9.

    7.Li L, Li X, Liu Y, Liu H*. (2016) Flowering responses to light and temperature. Sci China Life Science. doi:10.1007/s11427-015-4910-8

    8.Gao QF, Gu LL, Wang HQ, Fei CF, Fang X, Hussain J, Sun SJ, Dong JY, Liu H, Wang YF*. (2016) Cyclic nucleotide-gated channel 18 is an essential Ca2+ channel in pollen tube tips for pollen tube guidance to ovules in Arabidopsis. Proc Natl Acad Sci U S A. 113(11):3096-101.

    9.Zhang TQ, Lian H, Tang H, Dolezal K, Zhou CM, Yu S, Chen JH, Chen Q, Liu H, Ljung K, and Wang JW*. (2015) An intrinsic microRNA timer regulates progressive decline in shoot regenerative capacity in plants. The Plant Cell. 27(2):349-60.

    10.Tan ST, Dai C, Liu HT, and Xue HW*. (2013) Arabidopsis casein kinase1 proteins CK1.3 and CK1.4 phosphorylate cryptochrome 2 to regulate blue light signaling. The Plant Cell. 25: 2618-2632.

    11.Liu Y, Li X, Li K, Liu H*, Lin C (2013) Multiple bHLH proteins form heterodimers to mediate CRY2-dependent regulation of flowering-time in Arabidopsis, PLoS Genetics 9(10): e1003861

    12.Liu H*, Wang Q, Liu Y, Zhao X, Lin C* (2013) The Arabidopsis photoreceptors CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms. Proc Natl Acad Sci U S A 43:17582-17587

    13.Liu H*, GomezG, Lin S, Lin S, Lin C (2012) Optogenetic control of transcription in zebrafish. PLoS One. 2012;7(11):e50738.

    14.Wang Q, Fristedt R, Yu X, Chen Z, Liu H et al (2012). The γ-carbonic anhydrase subcomplex of mitochondrial complex I is essential for development and important for photomorphogenesis of Arabidopsis. Plant Physiology. doi: http://dx.doi.org/10.1104/pp.112

    15.Li X, Wang Q, Yu X, Liu H, Yang H et al (2011) Arabidopsis cryptochrome 2 (CRY2) functions by the photoactivation mechanism distinct from the tryptophan (trp) triad-dependent photoreduction. Proc Natl Acad Sci U S A 108(51):20844-20849.

    16.Liu H, Liu B. Zhao C, Pepper M and Lin C (2011). The action mechanisms of plant cryptochromes, Trends in Plant Sciences,16:684-691.

    17.Lu S#, Liu H#, Knowles S, Li J, Ma L, Tobin E, Lin C. (2011). A role for protein kinase CK2 alpha subunits in the Arabidopsis circadian clock. Plant Physiology 157: 1537-1545

    18.Zuo Z#, Liu H#, Liu B#, Liu X, Lin C.(2011) Blue Light-Dependent Interaction of CRY2 with SPA1 Regulates COP1 activity and Floral Initiation in Arabidopsis. (co-first author) Current Biology 21:841-847

    19.Liu B, Zuo Z, Liu H, Lin C. (2011). Arabidopsis cryptochrome 1 interacts with SPA1 to suppress COP1 activity in response to blue light. Gene & Development 25:1004-1009

    20.Liu B, Liu H, Zhong D, and Lin C. (2010). Searching for a photocycle of the Cryptochromephotoreceptors. Current Opinion in Plant Biology 13:1-9

    21.Liu H, Yu X, Li K, Klejnot J, Yang H, Lisiero D, Lin C. (2008). Photoexcited CRY2 interacts with CIB1 to regulate transcription and floral initiation in Arabidopsis. Science 322:1535-1539.

    22.Liu HT, Gao F, Li GL, Han JL, Liu DL, Sun DY, Zhou RG. (2008). The calmodulin-binding protein kinase 3 is part of heat-shock signal transduction in Arabidopsis thaliana. The Plant Journal 55(5):760-73.

    23.Liu HT, Li GL, Chang H, Sun DY, Zhou RG, Li B. (2007). Calmodulin-binding protein phosphatase PP7 is involved in thermotolerance in Arabidopsis. Plant Cell & Enviroment 30(2):156-64.

    24.Liu HT#, Gao F#, Sun DY, Zhou RG. (2006). Primary evidence for involvement of IP3 in heat-shock signal transduction in Arabidopsis. Cell Research 16(4):394-400

    25.Liu HT, Sun DY, Zhou RG. (2005). Ca2+ and AtCaM3 are Involved in the Expression of Heat Shock Protein Gene in Arabidopsis. Plant Cell & Environment 28:1276-1284.

    26.Li B, Liu HT,Sun DY, Zhou RG. (2004). Ca2+ and Calmodulin modulate DNA-binding activity of maize heat shock transcription factor in vitro. Plant Cell Physiology 45(5): 627-634.

    27.Liu HT,Li B, Shang ZL, Mu RL Sun DY, Zhou RG. (2003). Calmodulin is involved in heat shock signal transduction in wheat. Plant Physiology 132(7): 1186-1195.

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