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个人信息

博士生导师
研究员

Email: qhling@sippe.ac.cn
个人网页:

研究方向

叶绿体蛋白调控与植物发育

凌祺桦

个人简介

1999.9-2003.7 上海交通大学,本科

2003.9-2008.7 中国科学院植物生理生态研究所,博士

2008.7-2013.10 英国莱斯特大学,博士后

2013.10-2019.12 英国牛津大学,博士后

2020.1-至今 中国科学院澳门金莎娱乐app科学卓越创新中心,研究员/研究组长

研究工作

在农业生产中,高温、干旱等逆境胁迫是造成农作物减产的主要因素。叶绿体作为植物细胞中特有的细胞器,不仅是光合作用发生的场所,也是植物应对和适应逆境胁迫的重要调控单元。同时,叶绿体(以及其它相关质体)也是植物最重要的代谢中心,负责多种脂类、氨基酸、植物激素、色素的合成与降解,与许多重要的植物生物学过程和农艺性状有直接关联。而这些叶绿体功能的建立和维系,都依赖于叶绿体蛋白动态平衡(如蛋白转运、降解)的调控。本课题组主要以拟南芥、狗尾草和玉米为研究对象,围绕叶绿体蛋白调控机制这一中心问题,在光合作用、逆境反应和器官发育等关键领域开展研究。工作集中在以下3个方向:

1. 泛素-蛋白酶体途径降解叶绿体蛋白的分子机制

2. 叶绿体蛋白自噬的分子机制

3. 叶绿体蛋白调控在C4植物叶绿体分化中的功能

主要成果

    1.    Ling, Q.*, Broad, W.*, Trosch, R., Topel, M., Sert, T.D., Lymperopoulos, P., Baldwin A., Jarvis, RP. (2019) Ubiquitin-dependent chloroplast-associated protein degradation in plants. Science 22;363(6429). (Highlighted in Molecular Plants and Plantae, Recommended by F1000Prime)

    2.    Wu, GZ., Meyer, EH., Richter, AS., Schuster, M., Ling, Q., Sch?ttler, MA., Walther, D., Zoschke, R., Grimm, B., Jarvis, RP., Bock, R. (2019) Control of retrograde signalling by protein import and cytosolic folding stress. Nature Plants 5(5):525-538.

    3.    Ling, Q.*, Li, N*, Jarvis, RP. (2017) Chloroplast Ubiquitin E3 Ligase SP1: Does It Really Function in Peroxisomes? Plant Physiology 175(2):586-588.

    4.    Bédard, J.*, Tr?sch, R.*, Wu, F., Ling, Q., Flores-Pérez, ú., T?pel, M., Nawaz, F., Jarvis, RP. (2017)  New Suppressors of the Chloroplast Protein Import Mutant tic40 Reveal a Genetic Link between Protein Import and Thylakoid Biogenesis. Plant Cell. 29(7):1726-1747. (Recommended by F1000Prime)

    5.    Ling, Q. and Jarvis, RP. (2016) Analysis of Protein Import into Chloroplasts Isolated from Stressed Plants. J Vis Exp. 1;(117).

    6.    Ling, Q. and Jarvis, RP. (2016) Plant Signaling: Ubiquitin Pulls the Trigger on Chloroplast Degradation. Current Biology 11;26(1):R38-40.

    7.    Ling, Q. and Jarvis, RP (2015) Regulation of Chloroplast Protein Import by the Ubiquitin E3 Ligase SP1 Is Important for Stress Tolerance in Plants. Current Biology 5;25(19):2527-34.

    8.    Ling, Q. and Jarvis, RP. (2015) Functions of plastid protein import and the ubiquitin-proteasome system in plastid development. Biochim Biophys Acta. 1847(9):939-948.

    9.    Ling, Q. and Jarvis P. (2013) Dynamic regulation of endosymbiotic organelles by ubiquitination. Trends in Cell Biology 23(8):399-408.

    10. Ling, Q.*, Huang, W.*, Baldwin, A. and Jarvis, RP. (2012) Chloroplast biogenesis is regulated by direct action of the ubiquitin-proteasome system. Science 338(6107):655-659. (Highlighted in Science Perspective, Nat Rev Mol Cell Biol., Recommended by F1000Prime)

    11. Huang, W.*, Ling, Q.*, Bédard, J.*, Lilley, K. and Jarvis, RP. (2011) In vivo analyses of the roles of essential Omp85-related proteins in the chloroplast outer envelope membrane. Plant Physiology 157(1):147-159. (cover story)

    12. Ling, Q., Huang, W. and Jarvis, RP. (2011) Use of a SPAD-502 meter to measure leaf chlorophyll concentration in Arabidopsis thaliana. Photosynth. Res. 107(2): 209-214.

    13. Yao, Y.*, Ling, Q.*, Wang, H. and Huang, H. (2008) Ribosomal proteins promote leaf adaxial identity. Development 135: 1325-1334.

    Note: * co-first author

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