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个人信息

博士生导师
研究员
2015年获得“国家杰出青年基金”
Email: jwwang@sippe.ac.cn
个人网页: http://wanglab.sippe.ac.cn/

研究方向

植物时序性发育和生命周期

王佳伟

个人简介

1995-1999,上海交通大学生命科学与技术学院,学士
1999-2005,中国科学院上海生命科学研究院植物生理生态研究所,博士
2005-2011,Max Planck Institute for Developmental Biology,博士后
2011-,中国科学院上海生命科学研究院植物生理生态研究所,研究员

研究工作

年龄是多细胞生命体的基本特征之一。随着年龄的增长,生命体的生理与性状随之改变。常见的变化包括形态上的差异、再生能力的下降、代谢产物的异同以及对环境感应性的改变。与动物相比,植物的年龄策略又呈现出多样性。按照生活周期可分为:一年生(annual)、二年生(biennial)及多年生(perennial)。实验室以一年生草本植物--拟南芥(Arabidopsis thaliana)和十字花科多年生草本植物为模式,利用遗传学,反向遗传学、单细胞测序和细胞谱系追踪技术,回答如下一些科学问题:
1)植物如何从一个单细胞合子通过细胞分裂和分化发育成为一个多细胞的个体;
2)年龄不可逆的分子机理;
3)年龄如何调控植物再生能力和干细胞基因组的稳定性;
4)植物生活习性自然变异的遗传学基础;
5)多年生植物生活习性及其干细胞长久维持的分子机理。

主要成果

    1. Ye BB, Shang GD, Pan Y, Xu ZG, Zhou CM, Mao YB, Bao N, Sun L, Xu T, and Wang JW*. (2020). AP2/ERF Transcription Factors Integrate Age and Wound Signals for Root Regeneration Plant Cell. DOI: https://doi.org/10.1105/tpc.19.00378

    2. Li J, Mutanda I, Wang K, Yang L, Wang JW, and  Wang Y*. (2019). Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana. Nat Commun. 10: 4850.

    3. Ye BB, Zhang K, and Wang JW*. (2019). The Role of miR156 in Rejuvenation in Arabidopsis thaliana. J Integr Plant Biol. doi: 10.1111/jipb.12855.

    4. Zhang TQ#, Xu ZG#, Shang GD, and Wang JW*. (2019). A single-cell RNA sequencing profiles the developmental landscape of Arabidopsis root. Mol Plant. 12(5): 648-660.

    5. Wang L#, Zhou CM#, Mai YX, Li LZ, Gao J, Shang GD, Lian H, Han L, Zhang TQ, Tang HB, Ren H, Wang FX, Wu LY, Liu XL, Wang CS, Chen EW, Zhang XN, Liu C, and Wang JW*. (2019). A spatiotemporally regulated transcriptional complex underlies heteroblastic development of leaf hairs in Arabidopsis thaliana. EMBO J. 38(8): 100063.

    6. Zhang TQ, Lian H, Zhou CM, Xu L, Jiao YL, and Wang JW*. (2017). A Two-Step Model for de novo Activation of WUSCHEL during Plant Shoot Regeneration. Plant Cell. 29(5): 1073-1087.

    7. Wang J, Tian C, Zhang C, Shi B, Cao X, Zhang TQ, Zhao Z, Wang JW, and Jiao YL*. (2017). Cytokinin Signaling Activates WUSCHEL Expression during Axillary Meristem Initiation. Plant Cell. 29(6): 1373-1387.

    8. Liu C*, Cheng YJ, Wang JW, and Weigel D*. (2017). Prominent topologically associated domains differentiate global chromatin packing in rice from Arabidopsis. Nat Plants. 3(9):742-748.

    9. Wang J#, Cheng YJ#, Hu B, Ma X, Wang JW, and Liu C*. (2017). Non-random domain organization of the Arabidopsis genome at the nuclear periphery. Genome Res. 27(7): 1162-1173.

    10. Mao YB, Liu YQ, Chen DY, Chen FY, Fang X, Hong GJ, Wang LJ, Wang JW, and Chen XY*. (2017). Jasmonate response decay and defense metabolite accumulation contributes to age-regulated dynamics of plant insect resistance. Nat Commun. 8: 13925.

    11. Chen L, Tong J, Xiao L, Ruan Y, Liu J, Zeng M, Huang H, Wang JW, and Xu L*. (2016). YUCCA-mediated auxin biogenesis is required for cell fate transition occurring during de novo root organogenesis in Arabidopsis. J Exp Bot. 67: 4273-4284.

    12. Ma D, Hu Y, Yang C, Liu B, Fang L, Wan Q, Liang W, Mei G, Wang L, Wang H, Ding L, Dong C, Pan M, Chen J, Wang S, Chen S, Cai C, Zhu X, Guan X, Zhou B, Zhu S, Wang JW, Guo W, Chen XY, Zhang T*. (2016). Genetic basis for glandular trichome formation in cotton. Nat Commun. 7: 10456.

    13. Yu S, Lian H, and Wang JW*. (2015). Plant Developmental Transitions: the Role of MicroRNAs and Sugars. Curr Opin Plant Biol. 27: 1-7. (invited review)

    14. Wang L, and Wang JW*. (2015). Coding function for non-coding RNA in plants—insights from miRNA encoded peptide (miPEP). Sci China Life Sci. 58: 503-505.(Insight).

    15. Zhang TQ, Wang JW, and Zhou CM*. (2015). The role of miR156 in developmental transitions in Nicotiana tabacum. Sci China Life Sci. 58: 253-260.

    16. Zhang TQ, Lian H, Tang H, Dolezal K, Zhou CM, Yu S, Chen JH, Chen Q, Liu H, Ljung K, and Wang JW*. (2015). An Intrinsic MicroRNA Timer Regulates Progressive Decline in Shoot Regenerative Capacity in Plants. Plant Cell. 27(2): 349-360.

    17. Rubio-Somoza I, Zhou CM, Confraria A, Martinho C, Born P, Baena-Gonzalez E, Wang JW*, and Weigel D*. (2014). Temporal control of leaf complexity by miRNA-regulated licensing of protein complexes. Curr Biol. 24: 2714-2719.

    18. Wang JW*. (2014). Regulation of flowering time by miR156-mediated age pathway. J Exp Bot. 65: 4723-4730.

    19. Zhou CM, Zhang TQ, Wang X, Yu S, Lian H, Tang H, Feng ZY, Zozomova-Lihova J, and Wang JW*. (2013). Molecular Basis of Age-dependent Vernalization in Cardamine flexuosa. Science. 340: 1097-1100.

    20. Yu S, Cao L, Zhou CM, Zhang TQ, Lian H, Sun Y, Wu JQ, Huang JR, Wang GD, and Wang JW*. (2013). Sugar is an Endogenous Cue for Juvenile-to-Adult Phase Transition in Plants. eLife. 2: e00269.

    21. Zhou CM and Wang JW*. (2013). Regulation of Flowering Time by MicroRNAs. J Genet Genomics. 40: 211-215.

    22. Yu S#, Galvao V#, Zhang YC, Horrer D, Zhang TQ, Hao YH, Feng YQ, Wang S, Schmid M, and Wang JW*. (2012). Gibberellin Regulates Arabidopsis Floral Transition through miR156-Targeted SQUAMOSA PROMOTER BINDING-LIKE Transcription Factors. Plant Cell. 24(8): 3320-3332.

    23. Felipes FF, Wang JW, and Weigel D*. (2012). MIGS: miRNA induced gene silencing. Plant J. 70: 541-547.

    24. Gou JY, Felipes FF, Liu CJ, Weigel D, and Wang JW*. (2011). Negative Regulation of Anthocyanin Biosynthesis in Arabidopsis by a miR156-Targeted SPL Transcription Factor. Plant Cell. 23(4): 1512-1522.

    25. Wang JW*#, Park MY#, Wang LJ, Chen XY, Weigel D, and Poethig S*. (2011). MiRNA Control of Vegetative Phase Change in Trees. PLoS Genet. 7: e1002012.

    26. Laubinger S, Zeller G, Henz S, Buechel S, Sachsenberg T, Wang JWRatsch G, and Weigel D*. (2010). Global effects of the small RNA biogenesis machinery on the Arabidopsis thaliana transcriptome. PNAS. 107: 17466-17473.

    27. Wang JW, Czech B, Weigel D. (2009). miR156-regulated SPL transcription factors define an endogenous flowering pathway in Arabidopsis thaliana. Cell. 138: 738-749.

    28. Wu G, Park MY, Conway SR, Wang JW, Weigel D, Poethig S*. (2009). The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis. Cell. 138: 750-759.

    29. Wang JW, Schwab R, Czech B, Mica E, Weigel D*. (2008). Dual effects of miR156-Targeted SPL genes and CYP78A5/KLUH on plastochron length and organ size in Arabidopsis thaliana. Plant Cell. 20(5): 1231-1243.

    30. Mao YB, Cai WJ, Wang JW, Hong GJ, Tao XY, Wang LJ, Huang YP, Chen XY*. (2007). Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol. Nat Biotechnol. 25: 1307-1313.

    31. Wang JW, Wang LJ, Mao, YB, Cai WJ, Xue HW, Chen XY*. (2005). Control of root cap development by microRNA-targeted auxin response factors in Arabidopsis. Plant Cell. 17: 2204-2216.

    32. Wang S, Wang JW, Yu N, Li CH, Luo B, Gou JY, Wang LJ, Chen XY*. (2004). ntrol of plant trichome development by a cotton fiber MYB gene. Plant Cell. 6: 2323-2334.

    33. Xu YH, Wang JW, Wang S, Wang JY, and Chen XY*. (2004). Characterization of GaWRKY1, a cotton transcription factor that regulates the sesquiterpene synthase gene (+)-d-Cadinene synthase-A. Plant Physiol. 135: 507-515.

    34. Zhu YQ, Xu KX, Luo B, Wang JW, Chen XY*. (2003). An ATP-binding cassette transporter GhWBC1 from elongating cotton fibers. Plant Physiol. 133: 580-588.

    35. Li CH, Zhu YQ, Meng YL, Wang JW, Xu KX, Zhang TZ, Chen XY*. (2002). Isolation of genes preferentially expressed in cotton fibers by cDNA filter arrays and RT-PCR. Plant Science. 163: 1113-1120.

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