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个人信息

博士生导师
研究员
2012年获得“国家杰出青年基金”
Email: cswang@sibs.ac.cn
个人网页: http://sippe.ac.cn/wangcs/

研究方向

昆虫分子病理及真菌分子生物学

王成树

个人简介

1989.9–1993.7 安徽农业大学植保系, 学士;
1993.9–1996.7 安徽农业大学林学系, 硕士;
1998.9–2001.7 中国农业大学微生物系, 博士;
1999.8–2000.9 英国University of Wales Swansea,访问学者;
2001.7-2003.12 英国University of Wales Swansea, 博士后研究;
2004.1-2006.8 美国University of Maryland, 博士后研究;
2006.9- 应聘为中国科学院上海植物生理生态研究所,“百人计划”课题组长,研究员

研究工作

以真菌—昆虫互作为模型,研究:
1. 昆虫病理真菌的基因组进化学与种群遗传学;
2. 真菌—昆虫互作的蛋白效应机制;
3. 真菌—昆虫互作的化学生物学;
4. 真菌分子遗传与菌种退化的分子机理。

主要成果

1. 昆虫真菌基因组进化研究:揭示了昆虫真菌致病性进化的多起源性及协同进化特征,阐明了寄主不同的绿僵菌由专性菌经中间过渡物种向广谱菌方向进化的现象;
2. 真菌—昆虫互作的化学生物学研究:揭示了绿僵菌合成破坏素、白僵菌合成卵胞霉素的分子机理及其对于真菌杀虫毒力贡献的分子机理;首次发现蛹虫草能够合成喷司他丁,并由同一基因簇介导的虫草素与喷司他丁伴随生物合成机理;
3. 昆虫真菌致病机理研究:揭示了白僵菌或绿僵菌中LysM效应蛋白、细胞自噬相关基因、磷脂代谢及不同转录因子对于昆虫真菌细胞分化及致病毒力影响的分子机理等。

    1.Wang CS*, Wang SB. 2017. Insect pathogenic fungi: genomics, molecular interactions, and genetic improvements. Annual Review of Entomology, 62: 73-90.

    2.Xia YL, Luo FF, Shang YF, Chen PL, Lu YZ, Wang CS*. 2017. Fungal cordycepin biosynthesis is coupled with the production of the safeguard molecule pentostatin. Cell Chemical Biology, 24: 1479-1489.

    3.Cen K, Li B, Lu YZ, Zhang SW, Wang CS*. 2017. Divergent LysM effectors contribute to the virulence of Beauveria bassiana by evasion of insect immune defenses. PLoS Pathogens, 13(9): e1006004.

    4.Shang YF, Xiao GH, Zheng P, Cen K, Zhan S, Wang CS*. 2016. Divergent and convergent evolution of fungal pathogenicity. Genome Biology and Evolution, 8(5): 1374-1387.

    5.Feng P, Shang YF, Cen K, Wang CS*. 2015. Fungal biosynthesis of the bibenzoquinoe oosporein to evade insect immunity. Proceedings of the National Academy of Sciences USA, 112(36): 11365-11370.

    6.Shang YF, Feng P, Wang CS*. 2015. Fungi that infect insects: altering host behavior and beyond. PLoS Pathogens, 11(8): e1005037.

    7.Hu X, Xiao GH, Zheng P, Shang YF, Su Y, Zhang XY, Liu XZ, Zhan S, St. Leger RJ, Wang CS*. 2014. Trajectory and genomic determinants of fungal-pathogen speciation and host adaptation. Proceedings of the National Academy of Sciences USA, 111(47): 16796-16801.

    8.Li L, Hu X, Xia YL, Xiao GH, Zheng P, Wang CS.* 2014. Linkage of oxidative stress and mitochondrial dysfunctions to spontaneous culture degeneration in Aspergillus nidulans. Molecular & Cellular Proteomics, 13(2): 449-461.

    9.Duan ZB, Chen YX, Huang W, Shang YF, Chen PL, Wang CS*. 2013. Linkage of autophagy to fungal development, lipid storage and virulence in Metarhizium robertsii. Autophagy, 9(4): 538-549.

    10.Hu X, Zhang YJ, Xiao GH, Zheng P, Xia YL, Zhang XY, St Leger RJ, Liu XZ, Wang CS*. 2013. Genome survey uncovers the secrets of sex and lifestyle in caterpillar fungus. Chinese Science Bulletin, 58(23): 2846-2854. (cover story)

    11.Wang B, Kang QJ, Lu YZ, Bai LQ, Wang CS*. 2012. Unveiling the biosynthetic puzzle of destruxins in Metarhizium species. Proceedings of the National Academy of Sciences USA, 109(4): 1287-1292.

    12.Wang SY, Zhao G-P. Liu XZ, St. Leger RJ, Wang CS*. 2011. Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional Chinese medicine. Genome Biology, 12(11): R116.

    13.Gao Q, Jin K, Ying S-H, Zhang YJ, Xiao GH, Shang YF, Duan ZB, Hu X, Xie XQ, Zhou G, Peng GX, Luo ZB, Huang W, Wang B, Fang WG, Wang SB, Zhong Y, Ma L-J, St. Leger RJ, Zhao G-P, Pei Y, Feng M-G*, Xia YX*, Wang CS*. 2011. Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum. PLoS Genetics, 7(1): e1001264.

    14.Wang CS*, St Leger RJ*. 2007. A scorpion neurotoxin increases the potency of a fungal insecticide. Nature Biotechnology 25(12):1455-1456.

    15.Wang CS, St Leger RJ*. 2006. A collagenous protective coat enables Metarhizium anisopliae to evade insect immune responses. Proceedings of the National Academy of Sciences USA 103(17): 6647-6652.
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