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个人信息

博士生导师
研究员
2001年获得“国家杰出青年基金”
Email: zhhe@sibs.ac.cn
个人网页: http://sippe.ac.cn/zuhuahe

研究方向

植物抗病信号转导和水稻功能基因组学

何祖华

个人简介

1993-1996 浙江大学(原浙江农业大学)生物技术研究所植物分子生物学和植物病理学博士,副教授
1997-1998 美国加州Salk研究所植物细胞和分子生物学实验室博士后
1999-2000 加大Davis分校植物病理系博士后
2000,12-至今 获中国科学院引进国外人才计划资助,国家杰出青年基金获得者。任中国科学院上海植物生理生态研究所植物分子遗传国家重点实验室研究员,博导。
兼上海市第十一届、十二届、十三届政协委员,澳门金莎集团学会副理事长,国家973项目首席科学家,国家重点研发计划项目首席等。

研究工作

主要研究方向:植物抗病信号转导、功能基因和信号途径互作。
主要研究模式植物(水稻和拟南芥)抗病调控基因的克隆与信号转导, 重点研究水稻对真菌病害(稻瘟病和纹枯病)和拟南芥对水稻病害非寄主抗性的调控机制和信号途径,尤其是作物广谱抗病的基因及其分子机制;植物抗病(SA,JA途径)与发育(GA和auxin)和逆境信号间的cross-talk,逆境信号记忆机制;水稻重要农艺性状功能基因及其对田间(基础)抗病性的调节,并致力于广谱抗病和高产水稻资源的创造,目标是高抗与高产性状的协调与平衡。研究主要涉及分子遗传、植物病理学、细胞生物学、生物化学与生物信息学。

主要成果

1. 在广谱抗病机制与育种理论上取得重大突破。抗病性是育种的主要目标之一,稻瘟病是水稻的“癌症”,我国水稻品种审定采用抗瘟性“一票否决”制,但广谱与持久抗病的问题一直无法解决。其课题组发掘了我国特有的广谱抗瘟位点Pigm,经过长期研究发现其编码两个序列相似但功能拮抗的受体,通过蛋白互作和表观遗传调控广谱持久抗病与产量的平衡,由此解析了一种全新的植物免疫和广谱抗病机制,有效地解决了抗瘟育种的瓶颈问题,成果已被广泛应用于分子育种,已有品种大面积推广。其课题组系统解析细胞死亡因子等调控广谱抗病的新机制,并创造性地研究免疫嵌合受体的信号激发, 由此发现新的植物逆境记忆机制。

2.建立了抗病与产量性状互作的创新研究领域。抗病性往往伴随产量下降等抗性代价,机制复杂,是高抗高产育种的关键制约因子,受不同激素信号的调控。其在国际上较早提出抗病与产量等农艺性状协调的理念,并通过系统剖析激素(SA,JA,GA等)交互作用、受体激酶ER调控细胞死亡新机制等,将植物免疫与发育和抗逆信号耦合,创立了抗病—生理性状互作的理论体系,研究理念受到国际上广泛的认同。此外,为结合高抗与高产性状,课题组长期研究重要生理性状形成机制及其对田间抗性的影响,拓宽了植物病理研究方向,也为育种家创造了优异的高抗高产育种材料。

    1.  Yu Peng, Yingying Zhang, Yijie Gui, Dong An, Junzhong Liu, Xun Xu, Qun Li, Junmin Wang, Wen Wang, Chunhai Shi, Longjiang Fan, Baorong Lu, Yiwen Deng*, Sheng Teng* and Zuhua He* (2019) Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice. Mol Plant https://doi.org/10.1016/j.molp.2019.06.004

    2.  Keran Zhai, Yiwen Deng, Di Liang, Jun Tang, Jing Liu, Bingxiao Yan, Xin Yin, Hui Lin, Fudan Chen, Dongyong Yang, Zhen Xie, Jiyun Liu, Qun Li, Lin Zhang, Zuhua He* (2019) A new class of transcription factors regulates plant NLR-mediated immunity. Mol Cell 74, 1-14

    3.  Junzhong Liu, Lili Feng, Xueting Gu, Xian Deng, Qi Qiu, Qun Li, Yingying Zhang, Muyang Wang, Yiwen Deng, Ertao Wang, Yuke He, Isabel B?urle, Jianming Li, Xiaofeng Cao* and Zuhua He* (2019)  An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis. Cell Research 29:379–390

    4.  Zhen Xie, Bingxiao Yan, Jianrao Shou, Ju Tang, Meizhong Luo, Yiwen Deng*, Zuhua He* (2019) An NBS-LRR receptor pair confers broad-spectrum disease resistance through coordinating association in rice. Phil. Trans. R. Soc. B 374, 20180308

    5.  Xin Yin, Baohong Zou, Xuexue Hong, Mingjun Gao, Weibing Yang, Xiangbin Zhong, Yang He, Peng Kuai, Yonggen Lou, Jirong Huang, Jian Hua*, Zuhua He* (2018) Rice copine genes OsBON1 and OsBON3 function assuppressors of broad-spectrum disease resistance. Plant Biotechnology Journal 16(8):1476-1487

    6.  Mingjun Gao, Xin Yin, Weibing Yang, Sin Man Lam, Xiaohong Tong, Jiyun Liu, Xin Wang, Qun Li, Guanghou Shui, Zuhua He* (2017) GDSL Lipases modulate immunity through lipid homeostasis in rice. PLOS Pathogens 13(11), 1006724

    7.  Lin Zhang, Hong Yu, Bin Ma, Guifu Liu, Jianjun Wang, Junmin Wang, Rongcun Gao, Jinjun Li, Jiyun Liu, Jing Xu, Yingying Zhang, Qun Li, Xuehui Huang, Jianlong Xu, Jianming Li, Qian Qian, Bin Han, Zuhua He* & Jiayang Li* (2017) A natural tandem array alleviates epigenetic repression of IPA1 and leads to superior yielding rice. Nat Commun 8, 14789, DOI: 10.1038/ncomms14789

    8.  Yiwen Deng, Keran Zhai, Zhen Xie, Dongyong Yang, Xudong Zhu, Junzhong Liu, Xin Wang, Peng Qin, Yuanzhu Yang, Guomin Zhang, Qun Li, Jianfu Zhang, Shuangqing Wu, Jo?lle Milazzo, Bizeng Mao, Ertao Wang, Huaan Xie, Didier Tharreau, Zuhua He*(2017) Epigenetic regulation of antagonistic receptors confers rice blast resistance with yield balance. Science 355, 962-965

    9.  Quanyuan You, Keran Zhai, Donglei Yang, Weibing Yang, Jingni Wu, Junzhong Liu, Wenbo Pan, Jianjun Wang, Xudong Zhu, Yikun Jian, Jiyun Liu, Yingying Zhang, Yiwen Deng, Qun Li, Yonggen Lou, Qi Xie, Zuhua He* (2016) An E3 Ubiquitin Ligase-BAG Protein Module Controls Plant Innate Immunity and Broad-Spectrum Disease Resistance. Cell Host & Microbe 20, 758-769

    10.  Xiaozun Li, Donglei Yang, Li Sun, Qun Li, Bizeng Mao, and Zuhua He*(2016) The Systemic Acquired Resistance Regulator OsNPR1 Attenuates Growth by Repressing Auxin Signaling through Promoting IAA-Amido Synthase Expression. Plant Physiology 172: 546-555

    11.  Hui Shen, Xiangbin Zhong, Fangfang Zhao, Yanmei Wang, Bingxiao Yan, Qun Li, Genyun Chen, Bizeng Mao, Jianjun Wang, Yangsheng Li, Guoying Xiao, Yuke He, Han Xiao, Jianming Li, Zuhua He* (2015) ERECTA defines a major quantitative trait locus for heat survival and improves thermotolerance in transgenic plants. Nature Biotechnology 33: 996-1003

    12.  Jing Xu, Lin Zhang, Donglei Yang, Qun Li, Zuhua He* (2015) Thymidine kinases share conserved function for nucleotide salvage and play essential role for arabidopsis thaliana growth and development. New Phytologist 208: 1089-1103

    13.  Dawei Yan, Xiaoming Zhang, Lin Zhang, Shenghai Ye, Longjun Zeng, Jiyun Liu, Qun Li, Zuhua He* (2015) CURVED CHIMERIC PALEA 1 encoding an EMF1-like protein maintains epigenetic repression of OsMADS58 in rice palea development. Plant J 82: 12-24

    14.  Li Sun, Yu Kong, Donglei Yang, Ying Chen, Xiao-Zun Li, Long-Jun Zeng, Qun Li, Er-Tao Wang, Zu-Hua He* (2014) Sugar homeostasis mediated by cell wall invertase GIF1 plays a role in preexisted and induced defense in rice. Mol Plant Pathol. 15: 161-173 

    15.  Xiaodong Liu, Hong Zhang, Yang Zhao, Zhengyan Feng, Qun Li, Hong-Quan Yang, Sheng Luan, Jianming Li, Zu-Hua He* (2013) Auxin controls seed dormancy through stimulation of abscisic acid signaling by inducing ARF-mediated ABI3 activation in Arabidopsis. Proc Natl Acad Sci USA 110(38):15485-90

    16.  Weibing Yang, Mingjun Gao, Xin Yin, Jiyun Liu, Yonghan Xu, Longjun Zeng, Qun Li, Shubiao Zhang, Junmin Wang, Xiaoming Zhang, Zuhua He* (2013) Control of Rice Embryo Development, Shoot Apical Meristem Maintenance, and Grain Yield by a Novel Cytochrome P450 Mol Plant  6(6): 1945-960

    17.  Si-Hui Zhong, Jun-Zhong Liu, Hua Jin, Lin Lin, Qun Li, Ying Chen, Yue-Xing Yuan, Zhi-Yong Wang,Hai Huang, Yi-Jun Qi, Xiao-Ya Chen, Hervé Vaucheret, Joanne Chory, Jianming Li*, and Zu-Hua He* (2013)  Warm temperatures induce transgenerational epigenetic release of RNA silencing by inhibiting siRNA biogenesis in Arabidopsis. Proc Natl Acad Sci USA

    18.  Lin Lin, Si-Hui Zhong, Xiao-Feng Cui, Jianming Li, Zu-Hua He* (2012) Characterization of temperature sensitive mutants reveals a role for receptor-like kinase SCRAMBLED/STRUBBELIG in coordinating cell proliferation and differentiation during Arabidopsis leaf development. Plant J 72(5): 707-720

    19.  Xiaohong Tong, Jinfeng Qi, Xudong Zhu, Bizeng Mao, Longjun Zeng, Baohui Wang, Qun Li, Guoxin Zhou, Xiaojing Xu, Yonggen Lou*, Zuhua He* (2012) The rice hydroperoxide lyase OsHPL3 functions in defense responses by modulating the oxylipin pathway. Plant J 71, 763-775]

    20.  Dong-Lei Yang, Jian Yao, Chuan-Sheng Mei, Xiao-Hong Tong, Long-Jun Zeng, Qun Li, Lang-Tao Xiao, Tai-ping Sun, Jigang Li, Xing-Wang Deng, Chin Mei Lee, Michael F. Thomashow,Yinong Yang*, Zu-Hua He*, Sheng Yang He* (2012) Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade. Proc Natl Acad Sci USA 109: E1192-E1200

    21.  Yingying Zhang, Baichen Zhang, Dawei Yan, Weixin Dong, Weibing Yang, Qun Li, Longjun Zeng, Jianjun Wang, Linyou Wang, Leslie M. Hicks, Zuhua He* (2011) Two Arabidopsis cytochrome P450 monooxygenases CYP714A1 and CYP714A2 function redundantly in plant development through gibberellin deactivation. Plant J. 67: 342-353

    22.  Weibing Yang, Sulin Ren, Xiaoming Zhang, Mingjun Gao, Shenghai Ye, Yongbin Qi, Yiyan Zheng, Juan Wang, Longjun Zeng, Qun Li, Shanjin Huang, Zuhua He* (2011) BENT UPPERMOST INTERNODE1 encodes a class II formin FH5 crucial for actin organization and rice development. Plant Cell 23: 661-680.

    23.   Wei Li, Sihui Zhong, Guojun Li, Qun Li, Bizeng Mao, Yiwen Deng, Huijuan Zhang, Longjun Zeng, Fengming Song*, Zuhua He* (2011) Rice RING protein OsBBI1 with E3 ligase activity confers broad-spectrum resistance against Magnaporthe oryzae by modifying the cell wall defence. Cell Res 21: 835-848.

    24.  Ertao Wang, Jianjun Wang, Xudong Zhu, Wei Hao, Linyou Wang, Qun Li, Lixia Zhang, Wei He, Baorong Lu, Hongxuan Lin, Hong Ma, Guiquan Zhang and Zuhua He* (2008)  Control of rice grain-filling and yield by a gene with a potential signature of domestication. Nature Genetics 40, 1370-1374

    25.  Yingying Zhang, Yongyou Zhu, Yu Peng, Dawei Yan, Qun Li, Jianjun Wang, Linyou Wang, Zuhua He* (2008)  Gibberellin homeostasis and plant height control by EUI and a role for gibberellin in root gravity responses in rice. Cell Research  18, 412-421

    26.  Zhu YY, Takahito Nomura, Xu YH, Zhang YY, Peng Y, Mao BZ, Atsushi Hanada, Zhou HC Wang RX, Li PJ, Zhu XD, Lewis Mander, Yuji Kamiya, Shinjiro Yamaguchi, and He ZH* (2006)  ELONGATED UPPERMOST INTERNODE encodes a cytochrome P450 monooxygenase that epoxidizes gibberellins in a novel deactivation reaction in rice. Plant Cell 18, 442-456

     

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